Circulating filarial antigen detection in brugian filariasis.
Identifieur interne : 001302 ( Main/Exploration ); précédent : 001301; suivant : 001303Circulating filarial antigen detection in brugian filariasis.
Auteurs : Praveen Kumar Tripathi [Inde] ; Ramesh Chander Mahajan [Inde] ; Nancy Malla [Inde] ; Abhishek Mewara [Inde] ; Shailja Misra Bhattacharya [Inde] ; Ranganatha Krishna Shenoy [Inde] ; Rakesh Sehgal [Inde]Source :
- Parasitology [ 1469-8161 ] ; 2016.
Descripteurs français
- KwdFr :
- Adulte, Animaux, Antigènes d'helminthe (sang), Diéthylcarbamazine (usage thérapeutique), Femelle, Filariose lymphatique (immunologie), Filariose lymphatique (parasitologie), Filariose lymphatique (physiopathologie), Filariose lymphatique (traitement médicamenteux), Humains, Inde, Jeune adulte, Lapins, Maladies asymptomatiques, Mâle, Wuchereria bancrofti (croissance et développement), Wuchereria bancrofti (immunologie), Étapes du cycle de vie (immunologie).
- MESH :
- croissance et développement : Wuchereria bancrofti.
- immunologie : Filariose lymphatique, Wuchereria bancrofti, Étapes du cycle de vie.
- parasitologie : Filariose lymphatique.
- physiopathologie : Filariose lymphatique.
- sang : Antigènes d'helminthe.
- traitement médicamenteux : Filariose lymphatique.
- usage thérapeutique : Diéthylcarbamazine.
- Adulte, Animaux, Femelle, Humains, Inde, Jeune adulte, Lapins, Maladies asymptomatiques, Mâle.
English descriptors
- KwdEn :
- Adult, Animals, Antigens, Helminth (blood), Asymptomatic Diseases, Diethylcarbamazine (therapeutic use), Elephantiasis, Filarial (drug therapy), Elephantiasis, Filarial (immunology), Elephantiasis, Filarial (parasitology), Elephantiasis, Filarial (physiopathology), Female, Humans, India, Life Cycle Stages (immunology), Male, Rabbits, Wuchereria bancrofti (growth & development), Wuchereria bancrofti (immunology), Young Adult.
- MESH :
- chemical , blood : Antigens, Helminth.
- chemical , therapeutic use : Diethylcarbamazine.
- drug therapy : Elephantiasis, Filarial.
- growth & development : Wuchereria bancrofti.
- immunology : Elephantiasis, Filarial, Life Cycle Stages, Wuchereria bancrofti.
- parasitology : Elephantiasis, Filarial.
- physiopathology : Elephantiasis, Filarial.
- Adult, Animals, Asymptomatic Diseases, Female, Humans, India, Male, Rabbits, Young Adult.
Abstract
Human lymphatic filariasis (LF) is a major cause of disability globally. The success of global elimination programmes for LF depends upon effectiveness of tools for diagnosis and treatment. In this study on stage-specific antigen detection in brugian filariasis, L3, adult worm (AW) and microfilarial antigenaemia were detected in around 90-95% of microfilariae carriers (MF group), 50-70% of adenolymphangitis (ADL) patients, 10-25% of chronic pathology (CP) patients and 10-15% of endemic normal (EN) controls. The sensitivity of the circulating filarial antigen (CFA) detection in serum samples from MF group was up to 95%. In sera from ADL patients, unexpectedly, less antigen reactivity was observed. In CP group all the CFA positive individuals were from CP grade I and II only and none from grade III or IV, suggesting that with chronicity the AWs lose fecundity and start to disintegrate and die. Amongst EN subject, 10-15% had CFA indicating that few of them harbour filarial AWs, thus they might not be truly immune as has been conventionally believed. The specificity for antigen detection was 100% when tested with sera from various other protozoan and non-filarial helminthic infections.
DOI: 10.1017/S0031182015001675
PubMed: 26646772
Affiliations:
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Helminth</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Diethylcarbamazine</term></keywords><keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Filariose lymphatique</term><term>Wuchereria bancrofti</term><term>Étapes du cycle de vie</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Life Cycle Stages</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Antigènes d'helminthe</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Diéthylcarbamazine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Animals</term><term>Asymptomatic Diseases</term><term>Female</term><term>Humans</term><term>India</term><term>Male</term><term>Rabbits</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Animaux</term><term>Femelle</term><term>Humains</term><term>Inde</term><term>Jeune adulte</term><term>Lapins</term><term>Maladies asymptomatiques</term><term>Mâle</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Human lymphatic filariasis (LF) is a major cause of disability globally. The success of global elimination programmes for LF depends upon effectiveness of tools for diagnosis and treatment. In this study on stage-specific antigen detection in brugian filariasis, L3, adult worm (AW) and microfilarial antigenaemia were detected in around 90-95% of microfilariae carriers (MF group), 50-70% of adenolymphangitis (ADL) patients, 10-25% of chronic pathology (CP) patients and 10-15% of endemic normal (EN) controls. The sensitivity of the circulating filarial antigen (CFA) detection in serum samples from MF group was up to 95%. In sera from ADL patients, unexpectedly, less antigen reactivity was observed. In CP group all the CFA positive individuals were from CP grade I and II only and none from grade III or IV, suggesting that with chronicity the AWs lose fecundity and start to disintegrate and die. Amongst EN subject, 10-15% had CFA indicating that few of them harbour filarial AWs, thus they might not be truly immune as has been conventionally believed. The specificity for antigen detection was 100% when tested with sera from various other protozoan and non-filarial helminthic infections.</div></front></TEI><affiliations><list><country><li>Inde</li></country></list><tree><country name="Inde"><noRegion><name sortKey="Tripathi, Praveen Kumar" sort="Tripathi, Praveen Kumar" uniqKey="Tripathi P" first="Praveen Kumar" last="Tripathi">Praveen Kumar Tripathi</name></noRegion><name sortKey="Bhattacharya, Shailja Misra" sort="Bhattacharya, Shailja Misra" uniqKey="Bhattacharya S" first="Shailja Misra" last="Bhattacharya">Shailja Misra Bhattacharya</name><name sortKey="Mahajan, Ramesh Chander" sort="Mahajan, Ramesh Chander" uniqKey="Mahajan R" first="Ramesh Chander" last="Mahajan">Ramesh Chander Mahajan</name><name sortKey="Malla, Nancy" sort="Malla, Nancy" uniqKey="Malla N" first="Nancy" last="Malla">Nancy Malla</name><name sortKey="Mewara, Abhishek" sort="Mewara, Abhishek" uniqKey="Mewara A" first="Abhishek" last="Mewara">Abhishek Mewara</name><name sortKey="Sehgal, Rakesh" sort="Sehgal, Rakesh" uniqKey="Sehgal R" first="Rakesh" last="Sehgal">Rakesh Sehgal</name><name sortKey="Shenoy, Ranganatha Krishna" sort="Shenoy, Ranganatha Krishna" uniqKey="Shenoy R" first="Ranganatha Krishna" last="Shenoy">Ranganatha Krishna Shenoy</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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